HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → Ethyl 3-(1,2-dihydro-1-methyl-2-oxo-4-pyridinyl)-2-propenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Propanedioic acid, monoethyl ester | HCID 3595298 | — |
| Reactant | 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde | HCID 14293890 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Ethyl 3-(1,2-dihydro-1-methyl-2-oxo-4-pyridinyl)-2-propenoate | HCID 53764784 | — |
Reaction Steps
N-Methyl-4-formyl-2-pyridone* (30.17 g), monoethyl malonate (38.15 g), pyridine (150 ml) and piperidine (3 ml) were stirred under reflux for 61/2 hours. The reaction mixture was evaporated under reduced pressure to afford a residue which was crystallised from aqueous isopropanol to give ethyl β-(N-methyl-2-oxo-4-pyridyl)acrylate as a pale yellow solid (18.44 g), m.p. 126°-7° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04540699 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-ade9dd96662e495abdc2f1c14f53e4af |
| Source note | uspto-grants-1985_09 |