Ethyl 3-(1,2-dihydro-1-methyl-2-oxo-4-pyridinyl)-2-propenoate → HCID 20267138, compound

Participants

Reaction Steps

Ethyl β-(N-methyl-2-oxo-4-pyridyl)acrylate (26.28 g) in ethanol (170 ml) was hydrogenated over 5% palladium on charcoal (0.25 g) at 350 KPa (50 psi), with gentle warming, until theoretical uptake had been exceeded. The reaction mixture was filtered through diatomaceous earth and evaporated under reduced pressure to give ethyl β-(N-methyl-2-oxo-4-pyridyl)propionate as an oil (27.03 g) which was sufficiently pure for the next stage of the reaction sequence.

Provenance & Evidence