反应详情

2-Nitroamino-5-(1-methyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one (2.08 g) and 2-(2-dimethylaminomethyl-5-furylmethylthio)ethylamine (1.82 g) were refluxed in ethanol (10 ml) for 22 hours. The reaction mixture was evaporated under reduced pressure to afford an oil which on trituration with diethyl ether gave a solid. This solid was collected by filtration, washed with diethyl ether and recrystallised from isopropanol to yield 2-[2-(2-dimethylaminomethyl-5-furylmethylthio)ethylamino]-5-(1-methyl- 2-oxopyridin-4-ylmethyl)pyrimidin-4-one (1.41 g); recrystallisation from isopropanol afforded material with m.p. 129°-132° C.

1. customThe reaction mixture was evaporated under reduced pressure
2. customto afford an oil which on trituration with diethyl ether
3. customgave a solid
4. filtrationThis solid was collected by filtration
5. washwashed with diethyl ether
6. customrecrystallised from isopropanol