Ammonia → HCID 53857067, compound

Participants

Reaction Conditions

Reaction Steps

N-n-Butyl-4-formyl-2-pyridone (68.71 g), malonic acid (39.90 g), pyridine (225 ml) and piperidine (4.5 ml) were stirred under reflux for 6 hours. The reaction mixture was evaporated under reduced pressure to afford an oil, to which was added water and a small amount of ammonia ('880 solution) to aid dissolution. The solution was taken to pH 4 with acetic acid, the solvent volume was diminished under reduced pressure and acetone added to precipitate a solid. After cooling at 0° C. for a few hours the solid was collected by filtration, washed with acetone and dried in vacuo to afford β-(N-n-butyl-2-oxo-4-pyridyl)acrylic acid (62.06 g) as a white solid, m.p. 131°-134° C.

Provenance & Evidence