HCID 53712334, compound → HCID 20267135, compound

Participants

Reaction Steps

Ethyl β-(N-n-butyl-2-oxo-4-pyridyl)acrylate (59.50 g) in ethanol (150 ml) was hydrogenated over 5% palladium on charcoal (0.45 g) at 315 KPa (45 psi), with gentle warming. When the theoretical uptake of hydrogen had been exceeded the reaction mixture was filtered and the filtrate evaporated under reduced pressure to afford an oil. This oil was washed with petroleum ether (40°-60°) to yield ethyl β-(N-n-butyl-2-oxo-4-pyridyl)propionate (58.19 g).

Provenance & Evidence