5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 53653085, compound

Participants

Reaction Steps

2-(2-Dimethylaminomethyl-5-furylmethylthio)ethylamine (1.44 g) and 2-nitroamino-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one (1.76 g) were refluxed in pyridine (10 ml) for 24 hours. The reaction mixture was evaporated under reduced pressure to afford an oil which was washed with hot water. The mixture was allowed to cool overnight and the water was decanted to give the title compound as a residue. Ethanolic HCl (3 ml) and isopropanol were added with warming to give a solution which was evaporated under reduced pressure to give a residue which was recrystallised from isopropanolethanolic HCl to give 2-[2-(2-dimethylaminomethyl-5-furylmethylthio)ethylamino]-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one as a trihydrochloride salt (2.67 g), m.p. 169°-171.5° C.

Provenance & Evidence