HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-[2-[4-(Dimethylaminomethyl)pyrid-2-ylmethylthio]ethylamino]-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-(4-Dimethylaminomethyl-2-pyridylmethylthio)ethylamine | HCID 13277327 | — |
| Reactant | 2-Nitroamino-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one | HCID 18470132 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[2-[4-(Dimethylaminomethyl)pyrid-2-ylmethylthio]ethylamino]-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one | HCID 20267151 | — |
Reaction Steps
2-[4-(Dimethylaminomethyl)pyrid-2-ylmethylthio]ethylamine (0.90 g) and 2-nitroamino-5-(1-n-butyl-2-oxopyridin-4-ylmethyl)pyrimidin-4-one (1.12 g) were refluxed in ethanol (15 ml) for 72 hours. As the reaction had not gone to completion, the ethanol was replaced by pyridine (15 ml) and the mixture was refluxed for a further 6 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04540699 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-74dd31838d7645e0a4950c8f6ef49b03 |
| Source note | uspto-grants-1985_09 |