Hydrochloric Acid → 1-Benzyl-2,6-dimethylpyrazolo[1,5-b]-1,2,4-triazole

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Reaction Steps

2 g of the 7-acetyl-1-benzyl-2,6-dimethylpyrazolo[1,5-b]-1,2,4-triazole thus-obtained was dissolved in 20 ml of ethanol, to the solution was added 20 ml of concentrated hydrochloric acid and the mixture was refluxed by heating. After about 6 hours, the ethanol was distilled off under reduced pressure, the reaction mixture was rendered alkaline with a saturated aqueous solution of sodium hydrogencarbonate and extracted with ethyl acetate to obtain 1.6 g (95% yield) of almost pure deacetylated compound, i.e., 1-benzyl-2,6-dimethylpyrazolo[1,5-b]-1,2,4-triazole.

Provenance & Evidence