HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Difluoromethoxy)-6-methylpyrimidin-2-amine → N-(2-difluoromethoxyphenyl-sulfonyl)-N'-(4-difluoromethoxy-6-methylpyrimidin-2-yl)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Difluoromethoxy)-6-methylpyrimidin-2-amine | HCID 2817390 | — |
| Reactant | 2-Difluoromethoxybenzenesulfonylisocyanate | HCID 11096960 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(2-difluoromethoxyphenyl-sulfonyl)-N'-(4-difluoromethoxy-6-methylpyrimidin-2-yl)-urea | HCID 53792571 | 94.3% |
Reaction Steps
A mixture of 2.5 g of 2-difluoromethoxyphenyl-sulfonylisocyanate, 1.75 g of 2-amino-4-difluoromethoxy-6-methyl-pyrimidine and 30 ml of absolute dioxane is stirred at a temperature of 70° to 75° C. for 2 hours. The solution is concentrated by evaporation, and the residue is then crystallised from ether to obtain 4.0 g of N-(2-difluoromethoxyphenyl-sulfonyl)-N'-(4-difluoromethoxy-6-methyl-pyrimidin-2-yl)-urea, m.p. 163° to 164° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04540782 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-195c49486777401b9ce4d757074abec9 |
| Source note | uspto-grants-1985_09 |