Ethanol → HCID 13374891, compound

HRID 1719617Notes

Reaction equation

HRID 1719617 reaction equation
[C:1]1([C:7]2[S:8][C:9]3[C:14]([C:15](=[O:17])[CH:16]=2)=[CH:13][CH:12]=[CH:11][C:10]=3C=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20]([O:26][CH2:27][CH2:28][CH2:29][CH3:30])(=[O:25])[CH2:21][C:22]([CH3:24])=O.[NH2:31]/[C:32](/[CH3:36])=[CH:33]\[C:34]#[N:35].[CH2:37](O)C>>[C:34]([C:33]1[CH:37]([C:10]2[CH:11]=[CH:12][CH:13]=[C:14]3[C:9]=2[S:8][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:16][C:15]3=[O:17])[C:21]([C:20]([O:26][CH2:27][CH2:28][CH2:29][CH3:30])=[O:25])=[C:22]([CH3:24])[NH:31][C:32]=1[CH3:36])#[N:35]

Participants

5

Reactant 4

HCID 702EthanolHCID 11576Butyl acetoacetateHCID 5325263(2Z)-3-Amino-2-butenenitrileHCID 133748414-Oxo-2-phenyl-4H-1-benzothiopyran-8-carbaldehyde

Product 1

HCID 13374891HCID 13374891, compound

Procedure

10 mmol each of 2-phenyl-4-oxo-4H-thiochromen-8-aldehyde, butyl acetoacetate and 3-aminocrotononitrile were boiled under reflux in 30 ml of ethanol overnight, the mixture was concentrated and the residue was crystallized with ethyl acetate.

Workup

  1. concentrationthe mixture was concentrated
  2. customthe residue was crystallized with ethyl acetate

Sources & evidence

ORD record
ord-0bd9546d4eb94ed090e82e474ebaa98f
Source dataset
uspto-grants-1985_09
Patent number
US04540789

Reaction notes

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