HCID 13491246, compound → HCID 13491250, compound

Participants

Reaction Steps

13-Acetylamino-6,7,8,9,10,11-hexahydro-3-acetoxy-5-methyl-5,11-methanobenzocyclodecen-12(5H)-one (3 g., 0.008 mole) was refluxed with 10 mL of 20% hydrochloric acid in the presence of a few drops of ethanol for 24 hours. The reaction mixture was boiled with 0.5 g. of charcoal, filtered and the solvent was evaporated under reduced pressure. The remaining solid was recrystallized from acetone-ethanol (5:1) to afford 1.5 g. (65% yield) of the title compound as a hydrochloride dihydrate, mp 256°-258° C.

Provenance & Evidence