Methylamine → HCID 20266292, compound

Participants

Reaction Steps

500 ml of 33% ethanolic methylamine are added dropwise with cooling by ice/water to 105 g of 6-chloro-4-chloromethyl-2H-1-benzopyrane. Reaction is continued for 8 hours at room temperature, the mixture concentrated by evaporation and the residue taken up in dichloromethane. This solution is washed with 500 ml each of 1N NaOH and water, dried over MgSO4 and concentrated by evaporation. Distillation of the residue yields the title product b.p.: 116-120/13.3 Pascal.

Provenance & Evidence