Sodium Hydroxide → HCID 20266540, compound

HRID 1719698Notes

Reaction equation

HRID 1719698 reaction equation
Cl.Cl.[N:3]1([CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])[CH:7]=[N:6][CH:5]=[N:4]1.[OH-].[Na+].[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20](Cl)=[O:21]>C(Cl)Cl>[N:3]1([CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:20]([C:16]2[O:15][CH:19]=[CH:18][CH:17]=2)=[O:21])[CH:7]=[N:6][CH:5]=[N:4]1

Participants

5

Reactant 3

HCID 14798Sodium Hydroxide2×HCID 682422-Furancarbonyl chlorideHCID 20266537HCID 20266537, compound

Product 1

HCID 20266540HCID 20266540, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture of about 2.13 g of 1H-1,2,4-triazole-1-butanamine dihydrochloride, about 50 ml of methylene chloride, about 30 ml of 1N sodium hydroxide and about 1.47 ml of furoyl chloride was stirred for 16 hours and then treated with about 5 ml of 1N sodium hydroxide and about 50 ml of methylene chloride. The layers were separated and the organic layer was washed with water, dried and concentrated, giving the desired product, mp 78°-79° C.

Workup

  1. customThe layers were separated
  2. washthe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-4f8175e4edd74b60be228c68eaf7d25e
Source dataset
uspto-grants-1985_09
Patent number
US04542145

Reaction notes

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