Chloroform → 1-(Piperidin-4-yl)propan-1-ol

Participants

Reaction Steps

A solution of 4-propionyl pyridine (10.0 g) in acetic acid (100 cm3) was hydrogenated over platinum oxide (0.5 g) at 60° and 60 p.s.i. pressure for 60 hours. The mixture was filtered through "Avicel" and volatile material was removed in vacuo to give the crude acetate salt (12.0 g). A portion (1 g) was taken into chloroform (20 cm3), washed with 1M sodium hydroxide solution (10 cm3), dried and evaporated to afford 1-(4-piperidyl)propanol, m.p. 50° (0.70 g).

Provenance & Evidence