Methyl chloroformate → HCID 20266428, compound

HRID 1719713Notes

Reaction equation

HRID 1719713 reaction equation
Cl[C:2]([O:4][CH3:5])=[O:3].C([N:13]1[CH2:18][CH:17]=[C:16]([CH2:19][CH2:20][N:21]2[CH2:25][CH2:24][CH2:23][S:22]2(=[O:27])=[O:26])[CH2:15][CH2:14]1)C1C=CC=CC=1>C1(C)C=CC=CC=1>[CH3:5][O:4][C:2]([N:13]1[CH2:14][CH:15]=[C:16]([CH2:19][CH2:20][N:21]2[CH2:25][CH2:24][CH2:23][S:22]2(=[O:27])=[O:26])[CH2:17][CH2:18]1)=[O:3]

Participants

4

Reactant 2

HCID 6586Methyl chloroformateHCID 20266437HCID 20266437, compound

Product 1

HCID 20266428HCID 20266428, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Methyl chloroformate (3.3 cm3) was added at room temperature to a stirred solution of 2-[2-(1-benzyl-1,2,3,6-tetrahydropyrid-4-yl)ethyl]isothiazolidine-1,1-dioxide (4.5 g) in toluene (20 cm3) and the mixture was heated under reflux for 16 hours. Volatile material was removed in vacuo to give the crude 2-[2-(1-methoxycarbonyl-1,2,3,6-tetrahydropyrid-4-yl)ethyl]isothiazolidine-1,1-dioxide as an oil (5.0 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 16 hours
  3. customVolatile material was removed in vacuo

Sources & evidence

ORD record
ord-bd6ee1ba37f242759380154fa5850617
Source dataset
uspto-grants-1985_09
Patent number
US04542132

Reaction notes

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