Sodium Iodide → HCID 20266431, compound

Participants

Reaction Steps

A mixture of 1-[4-toluenesulphonyloxy]-2-[1-(6,7-dimethoxyquinazolin-4-yl)-4-hydroxy-piperid-4-yl]ethane (0.6 g) and sodium iodide (1.84 g) in butan-2-one (10 cm3) was heated under reflux for 2.5 hours. Volatile material was removed in vacuo and the residue partitioned between chloroform (20 cm3) and water (20 cm3). The dried (MgSO4) organic phase was evaporated and the residue was crystallized from ethyl acetate to afford 6,7-dimethoxy-4-[4-hydroxy-4-(2-iodoethyl)piperid-1-yl]quinazoline, m.p. 179°-181°, (0.3 g).

Provenance & Evidence