HCID 131714328, compound → HCID 131714327, compound

Participants

Reaction Steps

Trans-1-benzyl-3-t-butyldimethylsilyloxy-4-(1-triphenylmethoxyprop-2-yl)piperidine (4.5 g; diastereomer A) was hydrogenated in ethanol (60 cm3) at 60° and 60 p.s.i. pressure over 10% palladium on carbon (0.9 g) for 5 hours. The solution was cooled, filtered through "Avicel" to remove the catalyst and evaporated in vacuo to afford trans-3-t-butyldimethylsilyloxy-4-(1-hydroxyprop-2-yl)piperidine as a crude oil (diastereomer A).

Provenance & Evidence