Ammonia → 4,6-Bis(difluoromethoxy)pyrimidin-2-amine

HRID 1719788Notes

Reaction equation

HRID 1719788 reaction equation
[F:1][CH:2]([F:18])[O:3][C:4]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]=[C:6](S(C)(=O)=O)[N:5]=1.[NH3:19]>C(Cl)Cl>[F:1][CH:2]([F:18])[O:3][C:4]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]=[C:6]([NH2:19])[N:5]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 13491830HCID 13491830, compound

Product 1

HCID 134918234,6-Bis(difluoromethoxy)pyrimidin-2-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1.0 g of 4,6-bis(difluoromethoxy)-2-methylsulfonylpyrimidine in 20 ml of methylene chloride are added, with vigorous stirring, 5 ml of a 30% aqueous ammonia solution, in the course of which the reaction mixture warms up and is stirred for a further 2 hours. The solution is subsequently concentrated by evaporation and crystallised to thus obtain, in quantitative yield, (0.8 g) 4,6-bis(difluoromethoxy)-2-aminopyrimidine, m.p. 67°-69° C.

Workup

  1. concentrationThe solution is subsequently concentrated by evaporation
  2. customcrystallised

Sources & evidence

ORD record
ord-f363504391a647df890474337d5414c1
Source dataset
uspto-grants-1985_09
Patent number
US04542216

Reaction notes

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