HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fumarate → bromomesaconic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 2,5-Furandione, 3-(bromomethyl)- | HCID 10987076 | — |
| Reactant | HCID 86740308 | HCID 86740308 | — |
| Product | bromomesaconic acid | HCID 6449799 | — |
Reaction Steps
Steps are taken to avoid isomerization of 2-(bromomethyl)-maleic acid (3) to the corresponding fumarate analog by hydrolyzing the anhydride (2) in a dilute aqueous solution and neutralizing the diacid (3) immediately after complete hydrolysis. Any bromomethyl fumaric acid derivative formed is removed in purifying compound (4) as described in more detail below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04542225 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-43639ec7cebd449e9e16cfeaedc3e4fd |
| Source note | uspto-grants-1985_09 |