Pyridine → 2-Tridecyloxyethyl 2-trimethylammonioethyl phosphate

Participants

Reaction Steps

In benzene were dissolved 3.8 g of 2-n-tridecyloxyethanol and 5.7 g of 2-bromoethyl phosphorodichloridate, and following dropwise addition of 1.85 g of pyridine under ice-cooling, the mixture was stirred at room temperature. The reaction mixture was treated by the procedure of Production Example 1 including hydrolysis, quaternization, dehalogenation, purification by silica gel column chromatography and recrystallization from chloroform-acetone to give 2.2 g (34%) of the desired product. It was hygroscopic.

Provenance & Evidence