Hydrochloric Acid → HCID 53651268, compound

Participants

Reaction Steps

Into the same flask as in Example 1, N-(2-hydroxyethyl)-β-alanine (117 parts), sodium ethylate (68 parts), ethylene glycol (300 parts) and ethylene glycol monomethyl ether (150 parts) are charged, and the resultant mixture is heated at 100° C. under stirring. A mixture of vinylbenzyl chloride (152 parts) and ethylene glycol monomethyl ether (100 parts) is dropwise added thereto in 2 hours. Stirring under heating is further continued for 6 hours. The reaction mixture is neutralized with hydrochloric acid, and acetone is added thereto to precipitate a white solid substance. The white solid substance is collected by filtration and dried under reduced pressure to give N-(2-hydroxyethyl)-N-(vinylbenzyl)-β-alanine (191 parts) of the formula: ##STR21## of which the NMR chart is shown in FIG. 8.

Provenance & Evidence