HCID 20266005, compound → HCID 20266023, compound

Participants

Reaction Steps

9(N-Benzyl-N-butylaminomethyl)-6-methyl-1,2,3,4,7,8,9,10-octahydro-benzo[f]quinoline-3,10-dione hydrochloride (10 g) is dissolved in 300 ml of ethanol whereupon 2 g of 10% palladium-on-carbon is added, and the whole is kept under an atmosphere of hydrogen for 3 hours. The product partially crystallized out is dissolved well by adding methanol, and the catalyst is filtered off. The solvent is distilled off under reduced pressure, and the remaining crystals are recrystallized from ethanol to give 4.0 g of 9-butylaminomethyl-6-methyl-1,2,3,4,7,8,9,10-octahydro-benzo[f]quinoline-3,10-dione hydrochloride dihydrate as colorless needles, melting at 194°-196° C.

Provenance & Evidence