Sulfuric Acid → HCID 20266121, compound

HRID 1719885Notes

Reaction equation

HRID 1719885 reaction equation
C(O)(=O)C.[CH2:5]([CH:13]1[CH2:17][CH2:16][CH:15]([CH:18]([OH:28])[C:19]2[CH:24]=[CH:23][C:22]3[O:25][CH2:26][O:27][C:21]=3[CH:20]=2)[NH:14]1)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[S:29](=[O:33])(=[O:32])([OH:31])[OH:30]>C(O)C>[S:29](=[O:31])(=[O:30])([OH:33])[OH:32].[CH2:5]([CH:13]1[CH2:17][CH2:16][CH:15]([CH:18]([OH:28])[C:19]2[CH:24]=[CH:23][C:22]3[O:25][CH2:26][O:27][C:21]=3[CH:20]=2)[NH:14]1)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 86740341HCID 86740341, compound

Product 1

HCID 20266121HCID 20266121, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

1 g of ±2-[phenethyl]-5-[(3,4-methylenedioxy)-α-hydroxybenzyl]pyrrolidine acetate, prepared according to Example 15, is dissolved in a solution of 1 ml 50% aqueous sulfuric acid in 10 ml ethanol and the resulting precipitate is harvested. The product is suspended in ethanol and filtered, air dried, and recrystallized from methanol/acetone to yield ±2-[phenethyl]-5-[(3,4-methylenedioxy)-α-hydroxybenzyl]pyrrolidine bisulfate.

Workup

  1. filtrationfiltered
  2. customair dried
  3. customrecrystallized from methanol/acetone

Sources & evidence

ORD record
ord-95684fba84044f6e937d77cd7badd217
Source dataset
uspto-grants-1985_09
Patent number
US04543361

Reaction notes

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