1-(2-Tetrahydropyranyl)-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinone → HCID 131714339, compound

HRID 1719903Notes

Reaction equation

HRID 1719903 reaction equation
[CH2:1]([C@H:8]1[C@H:11]([CH2:12][CH2:13][OH:14])[NH:10][C:9]1=[O:15])[C:2]1C=CC=CC=1.[O:16]1CCCCC1N1C(CCOC2CCCCO2)CC1=O>>[OH:16][CH:1]([C@H:8]1[C@@H:11]([CH2:12][CH2:13][OH:14])[NH:10][C:9]1=[O:15])[CH3:2]

Participants

3

Reactant 2

HCID 143289841-(2-Tetrahydropyranyl)-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinoneHCID 67926856HCID 67926856, compound

Product 1

HCID 131714339HCID 131714339, compound

Procedure

Following the procedure described for the preparation of trans-3-benzyl-4-(2'-hydroxyethyl)-2-azetidinone from 8-oxo-2,2-dimethyl-7α-benzyl-3-oxa-1-azabicyclo[4.2.0]octane and using 8-oxo-2,2-dimethyl-7β-(1'-hydroxyethyl)-3-oxa-1-azabicyclo[4.2.0]octane one obtains cis-3-(1'-hydroxyethyl)-4-(2'-hydroxyethyl)-2-azetidinone.

Sources & evidence

ORD record
ord-11fbde2d25fa4ed09cb28e4cce418c47
Source dataset
uspto-grants-1985_09
Patent number
US04543257

Reaction notes

Loading…