Trimethyl orthoformate → 8-Oxo-2-methoxy-3-oxa-1-azabicyclo[4.2.0]octane

HRID 1719904Notes

Reaction equation

HRID 1719904 reaction equation
[O:1]=[C:2]1[N:9]2[CH:4]([CH2:5][CH2:6][O:7][C:8]2(C)C)[CH2:3]1.[CH:12](OC)(OC)[O:13]C>>[O:1]=[C:2]1[N:9]2[CH:4]([CH2:5][CH2:6][O:7][CH:8]2[O:13][CH3:12])[CH2:3]1

Participants

3

Reactant 2

HCID 9005Trimethyl orthoformateHCID 12769229HCID 12769229, compound

Product 1

HCID 199939978-Oxo-2-methoxy-3-oxa-1-azabicyclo[4.2.0]octane

Procedure

Following the procedure described for the preparation of 8-oxo-2,2-dimethyl-3-oxa-1-azabicyclo[4.2.0]octane from 4-(2'.hydroxyethyl)-2-azetidinone and using trimethyl orthoformate instead of 2,2-dimethoxypropane one obtains 8-oxo-2-methoxy-3-oxa-1-azabicyclo[4.2.0]octane.

Sources & evidence

ORD record
ord-203c819372d94d57989ceb84bfb414ac
Source dataset
uspto-grants-1985_09
Patent number
US04543257

Reaction notes

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