Acetic Acid → HCID 13060513, compound

HRID 1719918Notes

Reaction equation

HRID 1719918 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](CC)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[O-:12][C:13]#[N:14].[K+].[C:16](O)(=O)[CH3:17]>O>[C:4]([C:3]1[CH:6]=[C:7]([CH2:16][CH3:17])[CH:8]=[CH:9][C:2]=1[NH:1][C:13]([NH2:14])=[O:12])#[N:5]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 9942180HCID 9942180, compoundHCID 11378442Potassium cyanate

Product 1

HCID 13060513HCID 13060513, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a solution of 2-amino-4-ethylbenzonitrile (39.9 g) in acetic acid (200 ml) was added potassium cyanate (24.4 g) under ice-cooling in the course of 15 minutes and stirred overnight in water bath. To the resultant mixture was added water to give precipitates, which were separated by filtration, washed with water and dried at ambient temperature. The resultant crude crystals were recrystallized from ethanol to give crystalline (2-cyano-4-ethylphenyl)urea (29.0 g).

Workup

  1. temperaturecooling in the course of 15 minutes
  2. customto give
  3. customprecipitates
  4. customwhich were separated by filtration
  5. washwashed with water
  6. customdried at ambient temperature
  7. customThe resultant crude crystals were recrystallized from ethanol

Sources & evidence

ORD record
ord-76a26d48f3344c9e86bfb1723526bab2
Source dataset
uspto-grants-1985_09
Patent number
US04543356

Reaction notes

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