HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Dimethyl[{6-(3,3-dimethylbutyramido)-4-quinazolinylamino}methylene]propanedioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dimethyl methoxymethylenemalonate | HCID 90770 | — |
| Reactant | 4-Amino-6-(3,3-dimethylbutyramido)quinazoline | HCID 13060460 | — |
| Solvent | Water | HCID 962 | — |
| Product | Dimethyl[{6-(3,3-dimethylbutyramido)-4-quinazolinylamino}methylene]propanedioate | HCID 13060506 | 82.7% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 4amino-6-(3,3-dimethylbutyramido)-quinazoline (8.5 g), dimethyl methoxymethylenepropanedioate (12.75 g) and N,N-dimethylformamide (34 g) was stirred for an hour at 100° C. After cooling to ambient temperature, to the resultant mixture was added water to give precipitates, which were separated by filtration, washed with water and dried to give crystalline dimethyl [{6-(3,3-dimethylbutyramido)-4-quinazolinylamino}methylene]propanedioate (10.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04543356 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-a995adb2c6c4433f941535a0a7469fe5 |
| Source note | uspto-grants-1985_09 |