HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1719952Generated: October 26, 2026
Diphenyl Ether → methyl 4-oxo-10-(3,3-dimethylbutyramido)-4H-pyrimido[1,2-c]quinazoline-3-carboxylate
https://huagongshe.com/reaction/1719952
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | Dimethyl[{6-(3,3-dimethylbutyramido)-4-quinazolinylamino}methylene]propanedioate | HCID 13060506 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | methyl 4-oxo-10-(3,3-dimethylbutyramido)-4H-pyrimido[1,2-c]quinazoline-3-carboxylate | HCID 13060554 | 93.5% |
Reaction Steps
A mixture of dimethyl[{6-(3,3-dimethylbutyramido)-4-quinazolinylamino}methylene]propanedioate (7.30 g) and diphenylether (44 ml) was stirred at 260° C. for 10 minutes and then cooled to ambient temperature. To the mixture was added hexane to give crystals, which were filtered off and washed with hexane to give crystalline methyl 4-oxo-10-(3,3-dimethylbutyramido)-4H-pyrimido[1,2-c]quinazoline-3-carboxylate (6.28 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04543356 |
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| Source dataset | uspto-grants-1985_09 |
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| ORD ID | ord-3fb096e8712a42ba9c813b0db9a5784c |
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| Source note | uspto-grants-1985_09 |
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