HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1719966Generated: October 25, 2026
Diethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate → ethyl 4-oxo-10-(2-ethylbutyramido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate
https://huagongshe.com/reaction/1719966
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate | HCID 13060494 | — |
| Solvent | Diphenyl Ether | HCID 7583 | — |
| Product | ethyl 4-oxo-10-(2-ethylbutyramido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate | HCID 13302088 | 93.4% |
Reaction Steps
A mixture of diethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate (0.6 g) in diphenyl ether (3 ml) was stirred at 250° C. for 15 minutes and cooled to ambient temperature. The resulting crystals were filtered, washed with ethyl acetate and dried. There was obtained ethyl 4-oxo-10-(2-ethylbutyramido)-4H-pyrimido[1,2-C]quinazoline-3-carboxylate (0.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04543356 |
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| Source dataset | uspto-grants-1985_09 |
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| ORD ID | ord-348cf7e8f1c545a494f2f41b10dc2098 |
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| Source note | uspto-grants-1985_09 |
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