HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 4-Methylmorpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | N-Benzyloxycarbonyl-L-prolyl-L-alanine | HCID 73513 | — |
| Product | 4-Methylmorpholine | HCID 7972 | — |
| Product | Isobutyl chloroformate | HCID 62365 | — |
Reaction Steps
A suspension of 1.600 g (5.0 mmoles) of Z-(L)-Pro-(L)-AlaOH (Sigma) in 80 ml of dry methylene chloride (CH2Cl2) was brought in an argon atmosphere to a temperature of approximately -20° C. On stabilization of the temperature, the following were added in quick succession: 0.670 ml (5.13 mmoles) of isobutylchloroformate (IBCF) and 0.570 ml (5.17 mmoles) of 4-methylmorpholine (NMM), leaving the system under stirring for approximately 2 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05504071 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-d55adbf979bb4bf7bba49ceb8f1c0054 |
| Source note | uspto-grants-1996_04 |