Nitric Acid → HCID 22419890, compound

Participants

Reaction Conditions

Reaction Steps

To stirred nitric acid (99%; 25 ml) was added 1-ethoxycarbonyl-1,3-dihydro-6-fluoro-2,1-benzisothiazole 2,2-dioxide (2.78 g) in portions at 0° C. The mixture was stirred for 2 hours while allowing it to warm to 10° C. The reaction mixture was poured into ice-water mixture then, the resulting mixture was extracted with ethyl acetate. The organic layer was washed with saturated sodium bicarbonate solution. The extract was dried over magnesium sulfate and concentrated in vacuo. The resulting crude product was washed with methanol, to give 5-nitro-l-ethoxycarbonyl-1,3-dihydro-6-fluoro-2,1-benzisothiazole 2,2-dioxide (3.11 g).

Provenance & Evidence