HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1720037Generated: November 1, 2026
Ethanol → 4-(2-Phenyl-oxazol-4-ylmethoxy)benzaldehyde oxime
https://huagongshe.com/reaction/1720037
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 4-(2-Phenyl-4-oxazolylmethoxy)benzaldehyde | HCID 10826513 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2-Phenyl-oxazol-4-ylmethoxy)benzaldehyde oxime | HCID 85187608 | 97.1% |
Reaction Steps
A solution of 4-(2-phenyl-oxazol-4-ylmethoxy)benzaldehyde (4.3 g, 15.3 mmol), ethanol (100 mL), pyridine (45 mL) and hydroxylamine hydrochloride (2.2 g, 30.8 mmol) was refluxed for 1.5 hours. The solution is cooled to 25° C. and poured into water (600 mL). The resultant precipitate was filtered and dried at 25° C. for 18 hours to give the product as a white solid in 97.1% yield, m.p. 184°-186° C. MS (EI, m/e): 294 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05504097 |
|---|
| Source dataset | uspto-grants-1996_04 |
|---|
| ORD ID | ord-108f86ff92924a78987744c37fa2eebf |
|---|
| Source note | uspto-grants-1996_04 |
|---|
