反应详情

2-((3-Methyl-4-(2-(N-benzyl-N-ethoxycarbonylmethylamino)ethylthio)-2-pyridyl)methylthio)-1H-benzimidazole (1.0 g) was dissolved in ethanol (10 ml) and thereto was added an aqueous solution (3 ml) of 1N sodium hydroxide. The mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure and adjusted to pH 4 with an aqueous solution of dilute acetic acid. The resultant crystals were collected by filtration to give 2-((3-methyl-4-(2-(N-benzyl-N-carboxymethylamino)ethylthio)-2-pyridyl)methylthio)-1H-benzimidazole as colorless crystals.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. filtrationThe resultant crystals were collected by filtration