Sodium Hydroxide → HCID 15295558, compound

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Reaction Steps

The title compound is then prepared from the methyl ester as follows. 2N Sodium hydroxide (108 ml) is added to a solution of methyl 5-(4-n-heptylbenzoyl)pentanoate (22.8 g, 0.07 mole) in ethanol (216 ml) and the mixture heated under reflux for about 2 hours. The reaction mixture is cooled and extracted with ether (2×350 ml). The ether phase is discarded and the aqueous phase acidified (pH 2) with concentrated hydrochloric acid. The precipitate is collected by filtration, washed with water, and recrystallized from ethanol to give 5-(4-n-heptylbenzoyl) pentanoic acid (16.4 g) as colorless crystals, m.p. 80°-81° C.

Provenance & Evidence