monoMethyl adipate → HCID 15295562, compound

Participants

Reaction Steps

Adipic acid monomethyl ester (25 g; 0.16 mole) is converted to the acid chloride with thionyl chloride (25 g) in a manner analogous to that described in Example 1. The crude product is reacted with octylbenzene (200 ml) and aluminum chloride (40 g; 0.3 mole) and the product isolated in a manner analogous to that described in Example 1. The crude product Is heated under reflux with 2N sodium hydroxide (117 ml) and ethanol (117 ml) for 2 hours and further processed as described in Example 1. The crude product is recrystallized from heptane to give 5-(4-n-octylbenzoyl)pentanoic acid (38.2 g), m.p. 96°-97° C.

Provenance & Evidence