Hydrochloric Acid → HCID 15295564, compound

Participants

Reaction Steps

5-(3-nitro-4-n-heptylbenzoyl)pentanoic acid (0.7 g; 2.1 mole) is stirred overnight at room temperature in a mixture of stannous chloride (1.35 g) and concentrated hydrochloric acid (1.8 ml). The reaction product is mixed with excess 1M sodium hydroxide and washed with ether. The aqueous phase is acidified to pH 5 with dilute hydrochloric acid. The precipitate is collected and recrystallized from aqueous ethanol to give 5-(3-amino-4-n-heptylbenzoyl)pentanoic acid (0.46 g) as a cream colored crystalline solid, m.p. 100°-102° C. The structure is confirmed by NMR and IR spectroscopy.

Provenance & Evidence