反应详情

1-Bromohexane (45.0 g) is added to a solution of m-cresol (24.55 g), ethanol (500 ml) and 2N sodium hydroxide (113.5 ml), and the resulting mixture heated under reflux for 24 hours. The solution is then concentrated in vacuo and the residue extracted with ether (3×200 ml). The ether extracts are dried over magnesium sulfate, filtered, and concentrated to a dark brown oil, which is distilled in vacuo (b.p. 72° C., 0.05 mm Hg) to yield 3-n-hexyloxytoluene (39.5 g).

1. temperaturethe resulting mixture heated
2. temperatureunder reflux for 24 hours
3. concentrationThe solution is then concentrated in vacuo
4. extractionthe residue extracted with ether (3×200 ml)
5. dry with materialThe ether extracts are dried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated to a dark brown oil, which
8. distillationis distilled in vacuo (b.p. 72° C., 0.05 mm Hg)