L-Valine → HCID 53776099, compound

Participants

Reaction Steps

Triethylphosphite (7.09 g, 42.7 mmol), L-valine (5 g, 42.7 mmol) and hydrocinnamaldehyde (5.73 g, 42.7 mmol) are heated in acetic acid (15 mL) at 80° C. for 4 h. After evaporating the solvent, the solid is dissolved in 5% sodium bicarbonate solution, washed with ether and acidified to pH =4. The aqueous mixture is extracted with ethyl acetate, dried and evaporated to afford the title compound.

Provenance & Evidence