Sodium Hydroxide → HCID 178524704, compound

Participants

Reaction Steps

A mixture of 8-carboethoxy-9-hydroxy-1H-pyrazolo[3,4-f]quinoline (12.31 g, 47.8 mmol) and 10% aqueous sodium hydroxide (96 ml) was refluxed for 8 hours, at which time the dark-colored solution was treated with decolorizing carbon and filtered through diatomaceous earth (Celite™). The filtrate was neutralized with 6M HCl and the resulting precipitate isolated by filtration. The light brown solid was air dried to give 8-carboxy-9-hydroxy-1H-pyrazolo[3,4-f]quinoline (10.08 g, 92%).

Provenance & Evidence