HCID 178524704, compound → HCID 178516374, compound

HRID 1720258Notes

Reaction equation

HRID 1720258 reaction equation
C([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[OH:14])=[C:11]1[NH:15][N:16]=[CH:17][C:10]1=[CH:9][CH:8]=2)(O)=O>N1C2C(=CC=CC=2)C=CC=1C>[OH:14][C:13]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]3[CH:17]=[N:16][NH:15][C:11]3=2)[N:6]=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 178524704HCID 178524704, compound

Product 1

HCID 178516374HCID 178516374, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 70602-MethylquinolineSolvent

Procedure

A mixture of 8-carboxy-9-hydroxy-1H-pyrazolo[3,4-f]quinoline (5.00 g, 21.8 mmol) and quinaldine (50 ml) were refluxed for 20 hours. After cooling, the precipitate was collected by filtration and washed thoroughly with ether to give 9-hydroxy-1H-pyrazolo[3,4-f]quinoline (2.97 g, 74%).

Workup

  1. temperaturewere refluxed for 20 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitate was collected by filtration
  4. washwashed thoroughly with ether

Sources & evidence

ORD record
ord-858fcfc573d649eda9e9f7be48424417
Source dataset
uspto-grants-1996_04
Patent number
US05506235

Reaction notes

Loading…