Sodium Hydroxide → HCID 15621416, compound

Participants

Reaction Conditions

Reaction Steps

4-Hydroxy-6-nitro-2-phenylquinoline (10.00 g, 38 mmol) was suspended in phosphorus oxychloride (POCl3) (57.58 g, 380 Mol) at 0° C. Dimethylformamide (DMF) (45 ml) was added dropwise and the resulting mixture heated at 70° C. for 5 hours. The reaction was cooled and then poured onto ice. The pH was adjusted to 6 with aqueous sodium hydroxide and the precipitate collected by vacuum filtration and dried in a vacuum oven to give 4-chloro-6-nitro-2-phenylquinoline (10.95 g, 102%) as a yellow powder.

Provenance & Evidence