反应详情

A solution of 1.0 g (4.5 mmol) of 4-chloro-2-methyl-8-nitroquinoline, 1.0 g (4.9 mmol) of 4-(cyclohexylmethyloxy)aniline and 30 mL of ethanol was heated under reflux for five hours. After cooling to room temperature, the reaction solution was evaporated to a residue which was slurried in in diethyl ether and filtered to furnish 2.0 g (99%) of N-[4-(cyclohexylmethyloxy)phenyl]-2-methyl-8-nitroquinolin-4-amine hydrochloride hydrate: m.p. 211°-214° C. (uncorr.).

1. temperatureunder reflux for five hours
2. customthe reaction solution was evaporated to a residue which
3. filtrationfiltered