4-Chloroaniline → HCID 22417821, compound

HRID 1720267Notes

Reaction equation

[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:3]=1.[Cl:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][CH:22]=1>>[OH2:12].[ClH:1].[Cl:20][C:21]1[CH:27]=[CH:26][C:24]([NH:25][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=[C:4]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:3]=2)=[CH:23][CH:22]=1

Participants

Reactant 2

HCID 78124-Chloroaniline

HCID 7370144-chloro-6-methoxy-2-phenylquinoline

Product 1

HCID 22417821HCID 22417821, compoundYield 80%

Procedure

In a manner similar to that described in Example 35, part A, 4-chloro-6-methoxy-2-phenylquinoline and 4-chloroaniline were transformed into 1.2 g (80%) of the title compound: m.p.>250° C.

Sources & evidence

ORD record: ord-f1114d68004f4bac84c9a83baca1b963
Source dataset: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05506235

Reaction notes

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