3-Methoxyaniline → 4-(3-Methoxyphenylamino)-2-methylquinolin-6-ol Hydrochloride

HRID 1720270Notes

Reaction equation

HRID 1720270 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[C:4]([CH3:13])[CH:3]=1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=1>>[ClH:1].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([NH:22][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=3)[N:5]=[C:4]([CH3:13])[CH:3]=2)[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 108243-MethoxyanilineHCID 7715204-Chloro-2-methylquinolin-6-ol

Product 1

HCID 224179614-(3-Methoxyphenylamino)-2-methylquinolin-6-ol Hydrochloride

Procedure

In a manner similar to that described in Example 39, Part B, 4-chloro-2-methylquinolin-6-ol and m-anisidine were converted into the title compound: m.p. 309°-311° C.

Sources & evidence

ORD record
ord-e5335d8a97b44c7d88b120fcb171a30c
Source dataset
uspto-grants-1996_04
Patent number
US05506235

Reaction notes

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