4-(Cyclohexylmethoxy)aniline → HCID 22417939, compound

HRID 1720286Notes

Reaction equation

HRID 1720286 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH:17]1([CH2:23][O:24][C:25]2[CH:31]=[CH:30][C:28]([NH2:29])=[CH:27][CH:26]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[ClH:1].[CH:17]1([CH2:23][O:24][C:25]2[CH:31]=[CH:30][C:28]([NH:29][C:2]3[C:11]4[C:6](=[CH:7][CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=4)[N:5]=[CH:4][CH:3]=3)=[CH:27][CH:26]=2)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 156816514-(Cyclohexylmethoxy)anilineHCID 22417892Ethyl 4-chloroquinoline-6-carboxylate

Product 1

HCID 22417939HCID 22417939, compound

Procedure

In a manner similar to that described in Example 39, Part B., 2.0 g (8.48 mmol) of ethyl 4-chloroquinolin-6-carboxylate and 1.74 g (8.48 mmol) of 4-(cyclohexylmethyloxy)aniline were transformed into the title compound: yield 3.41 g (92%); m.p. 251°-253° C.

Sources & evidence

ORD record
ord-b9bbafaa82e64ba188808bf816c2f825
Source dataset
uspto-grants-1996_04
Patent number
US05506235

Reaction notes

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