Isopropanol → 5-(2-Chlorobenzyl)-4-methoxymethyl-beta-carboline-3-carboxylic acid isopropyl ester

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Reaction Steps

0.2 g (5 mmol) of 5-(2-chlorobenzyl)-4-methoxymethyl-β-carboline-3-carboxylic acid ethyl ester is refluxed for 2 hours in 35 ml of isopropanol with 0.15 ml (0.5 mmol) of titanium tetraisopropylate. The mixture is filtered and the filtrate concentrated by evaporation to approximately a third. 0.112 g (54% of theory) of 5-(2-chlorobenzyl)-4-methoxymethyl-β-carboline-3-carboxylic acid isopropyl ester crystallizes out, melting point 187°-189° C.

Provenance & Evidence