Imidazole → HCID 131719374, compound

Participants

Reaction Steps

1.5 g (0.0022 mol) of imidazole in 20 ml of tetrahydrofuran is mixed with 0.4 ml (0.0054 mol) of thionylchloride dissolved in 5 ml of tetrahydrofuran. The precipitate is suctioned off, the filtrate is instilled in a suspension of 0.693 g (0.00163 mol) of 5-(2-chlorobenzyl)-4-methoxyethoxymethyl-β-carboline-3-carboxylic acid in 30 ml of tetrahydrofuran. After it is left standing overnight the solvent is distilled off, the residue is dissolved in ethyl acetate, the solution is washed imidazole free with water. After concentration by evaporation 0.55 g (71% of theory) of 5-(2-chlorobenzyl)-4-methoxyethoxymethyl-β-carboline-3-carboxylic acid imidazolide remains.

Provenance & Evidence