HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Tert-butyl 2-(aminomethyl)-2-ethylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Tert-butyl 2-cyano-2-ethylbutanoate | HCID 54237674 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Tert-butyl 2-(aminomethyl)-2-ethylbutanoate | HCID 54399069 | — |
Reaction Steps
29.21 g of 2-cyano-2-ethylbutyric acid tert-butyl ester, dissolved in 300 ml of ethanol, which contains 4% ammonia, are hydrogenated under normal pressure at 40° in the presence of 6 g of Raney nickel. After separating off from the catalyst, the batch is concentrated by evaporation in vacuo and the liquid that remains is distilled in vacuo to yield 2-aminomethyl-2-ethylbutyric acid tert-butyl ester, boiling point 65° at 0.6 mbar.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506240 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-3b1757af0686452099323989689ba767 |
| Source note | uspto-grants-1996_04 |