HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 8-Methoxychroman-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 8-methoxy-chroman-2-carboxylate | HCID 18787171 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-Methoxychroman-2-carboxylic acid | HCID 15229196 | 106.3% |
Reaction Steps
The mixture of 100.7 g (0.43 mol) 8-methoxy-2-chromancarboxylic acid ethyl ester and 20.1 g (0.50 mol) sodium hydroxide in 800 ml ethanol was stirred for 24 h at 20°. After evaporation, the residue was treated with water and extracted with diethyl ether. The aqueous phase was acidified and then extracted with diethylether. Usual work-up yielded 95.2 g of crystalline 8-methoxychroman-2-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506246 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-4bd69051d8c546f49c055270fc8434a8 |
| Source note | uspto-grants-1996_04 |