m-Chloroperbenzoic acid → Pyridine, 2-methyl-5-(trifluoromethyl)-, 1-oxide

Participants

Reaction Steps

To a solution of crude 2-methyl-5-trifluoromethylpyridine from Step 1 (3.8 g) in CHCl3 (40 mL) was added m-chloroperbenzoic acid (3.0 g, 17.4 mmol) and the resulting mixture was stirred 5 hours at r.t. More peracid (1.5 g, 8.7 mmol) was added and the reaction stirred another 2 hours. Calcium hydroxide (3.0 g, 40.5 mmol) was added and the slurry was vigorously stirred 20 minutes before filtering through celite. Evaporation of the solvents gave 4.5 g of the title compound containing a little dioxane and CHCl3. This material was used without further purification.

Provenance & Evidence